I really haven't noticed anything too concerning. Once or twice when I've been at full lock while backing up, I must've heard the mud flaps rub up against the tires?? But no driveability issues.
I have the 2.7. Some pics of the PBs make it seem like it sits a hair lower? @2021f150 ran 285/65/20...
Here's a few pics of mine with 285/65/20 KO2s. No issues to report... dealer wouldn't install them though, said they wouldn't fit...
Edit: no lift/level. All stock