Thanks for your info. That answers my question.Are these the wheels you have on your F-150?
I did a little research for you, from what I can tell you are safe using a flat head screwdriver or pry bar. A lot of the sources I read recommended tips by using a towel to place against the area why you will be prying, or sticking the tool inside a glove so you minimize the risk of scratching or otherwise damaging the wheel.
Here is a video showing how to remove a Ford center hub cap. Its from a twelfth generation F-150, but the overall premise should still be the same. Hope this helps!
Thanks for your info. That answers my question.